miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression
نویسندگان
چکیده
منابع مشابه
MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.
OBJECTIVE Lineage-negative bone marrow cells (lin- BMCs) are enriched in endothelial progenitor cells and mediate vascular repair. Aging-associated senescence and apoptosis result in reduced number and functionality of lin- BMCs, impairing their prorepair capacity. The molecular mechanisms underlying lin- BMC senescence and apoptosis are poorly understood. MicroRNAs (miRNAs) regulate many impor...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2017
ISSN: 0014-5793
DOI: 10.1002/1873-3468.12720